期刊论文详细信息
Journal of genetics | |
Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system | |
Jason P. Debruyne11  | |
[1] Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, 835 BRBII/III, 421 Curie Blvd, Philadelphia, PA 19104, USA$$ | |
关键词: Clock gene; suprachiasmatic nucleus (SCN); circadian rhythms; biological clocks; negative feedback loops; CLOCK; NPAS2.; | |
DOI : | |
学科分类:生物科学(综合) | |
来源: Indian Academy of Sciences | |
【 摘 要 】
A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian clockwork function, based mainly on studies of mice bearing a dominant negative, antimorphic mutation in the Clock gene. However, new discoveries using recently developed Clock-null mutant mice have shaken up this view. In this review, I discuss how this recent work impacts and alters the previous view of the role of CLOCK in the mouse circadian clockwork.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912040490775ZK.pdf | 796KB | download |