Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system

Journal of genetics

Jason P. Debruyne1¹ 

[1] Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, 835 BRBII/III, 421 Curie Blvd, Philadelphia, PA 19104, USA$$

关键词: Clock gene;    suprachiasmatic nucleus (SCN);    circadian rhythms;    biological clocks;    negative feedback loops;    CLOCK;    NPAS2.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian clockwork function, based mainly on studies of mice bearing a dominant negative, antimorphic mutation in the Clock gene. However, new discoveries using recently developed Clock-null mutant mice have shaken up this view. In this review, I discuss how this recent work impacts and alters the previous view of the role of CLOCK in the mouse circadian clockwork.

【 授权许可】

Unknown