Dissecting the correlation structure of a bivariate phenotype: common genes or shared environment?

Journal of genetics

Saurabh Ghosh1¹ 

[1] Human Genetics Unit, Indian Statistical Institute, 203 BT Road, Kolkata 700 108, India$$

关键词: Bombyx mori;    Bombyx mandarina;    mitochondrial DNA;    cytochrome b gene;    phylogenetic tree.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

High correlations between two quantitative traits may be either due to common genetic factors or common environmental factors or a combination of both. In this study, we develop statistical methods to extract the genetic contribution to the total correlation between the components of a bivariate phenotype. Using data on bivariate phenotypes and marker genotypes for sib-pairs, we propose a test for linkage between a common QTL and a marker locus based on the conditional cross-sib trait correlations (trait 1 of sib 1 – trait 2 of sib 2 and conversely) given the identity-by-descent (i.b.d.) sharing at the marker locus. We use Monte-Carlo simulations to evaluate the performance of the proposed test under different trait parameters and quantitative trait distributions. An application of the method is illustrated using data on two alcohol-related phenotypes from a project on the collaborative study on the genetics of alcoholism.

【 授权许可】

Unknown