sY116, a human �-linked polymorphic STS

Journal of genetics

I. Manorama Thomas¹  Reiner Veitia²  Houssein Khodjet El Khil⁴  G. Mustafa Saifi1³  Marc Fellous²  Preetha Tilak¹  Sandrine Barbaux² 

[1] Department of Anatomy, St John's Medical College, Bangalore 560 034, India$$;Immunogénétique Humaine, Institut Pasteur, 75724 Paris, Cedex 15, France$$;Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India$$;Laboratoire d'Immunogénétique, Faculté de Sciences de Tunis, Tunis, Tunisia$$

关键词: male infertility;    polymorphism;    Y chromosome;    mitotic instability.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

During a study of deletions of Y-chromosomal DNA in infertile males, sY116, a Y-linked STS, showed different electrophoretic mobilities in three males, two infertile and one fertile. A study of this STS among 35 other normal males showed that this locus is polymorphic. sY116 has a poly A-rich stretch whose instability appears to be the most likely cause of this polymorphism. The possible usefulness of sY116 polymorphism in the detection of subtle genome-wide instabilities in some types of cancer is discussed.

【 授权许可】

Unknown