The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A2A receptors

Purinergic Signalling

Josiane Budni³  Adair R. S. Santos³  Manuella P. Kaster¹  Ana Lúcia S. Rodrigues³  Mauricio P. Cunha³  Marta Gazal² 

[1] Universidade Católica de Pelotas (UCPel)$$Universidade Católica de Pelotas$$;Universidade Católica de Pelotas (UCPel)$$;Universidade Federal de Santa Catarina$$

关键词: Forced swimming test;   

DOI  :  10.1007/s11302-013-9361-8

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Inosine is an endogenous purine nucleoside, which is formed during the breakdown of adenosine. The adenosinergic system was already described as capable of modulating mood in preclinical models; we now explored the effects of inosine in two predictive models of depression: the forced swim test (FST) and tail suspension test (TST). Mice treated with inosine displayed higher anti-immobility in the FST (5 and 50 mg/kg, intraperitoneal route (i.p.)) and in the TST (1 and 10 mg/kg, i.p.) when compared to vehicle-treated groups. These antidepressant-like effects started 30 min and lasted for 2 h after intraperitoneal administration of inosine and were not accompanied by any changes in the ambulatory activity in the open-field test. Both adenosine A₁ and A_2A receptor antagonists prevented the antidepressant-like effect of inosine in the FST. In addition, the administration of an adenosine deaminase inhibitor (1 and 10 mg/kg, i.p.) also caused an antidepressant-like effect in the FST. These results indicate that inosine possesses an antidepressant-like effect in the FST and TST probably through the activation of adenosine A₁ and A_2A receptors, further reinforcing the potential of targeting the purinergic system to the management of mood disorders.

【 授权许可】

Unknown