Emerging role of extracellular nucleotides and adenosine in multiple sclerosis

Purinergic Signalling

Filip Kukulski²  Michał Komoszyński¹  Marek Cieślak³ 

[1] Nicolaus Copernicus University$$;Centre Hospitalier Universitaire de Québec$$;WSZ Hospital$$

关键词: P1 receptor;   

DOI  :  10.1007/s11302-011-9250-y

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Extracellular nucleotides and adenosine play important roles in inflammation. These signaling molecules interact with the cell-surface-located P2 and P1 receptors, respectively, that are widely distributed in the central nervous system and generally exert opposite effects on immune responses. Indeed, extracellular ATP, ADP, UTP, and UDP serve as alarmins or damage-associated molecular patterns that activate mainly proinflammatory mechanisms, whereas adenosine has potent anti-inflammatory and immunosuppressive effects. This review discusses the actual and potential role of extracellular nucleotides and adenosine in multiple sclerosis (MS).

【 授权许可】

Unknown