P2 receptors in macrophage fusion and osteoclast formation

Purinergic Signalling

Thomas H. Steinberg²  Jeffrey F. Hiken¹ 

[1] Washington University School of Medicine$$;Washington University School of Medicine$$Infectious Diseases$$

关键词: purinergic receptors;   

DOI  :  10.1007/s11302-006-9036-9

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X₇, are involved in this process, although P2X₇ is not absolutely required for fusion because P2X₇-null mice form multinucleated osteoclasts. Extracellular ATP may be an important regulator of macrophage fusion.

【 授权许可】

Unknown