The role of P2 receptors in controlling infections by intracellular pathogens

Purinergic Signalling

Cristiane Monteiro da Cruz³  Robson Coutinho-Silva¹  Pedro M. Persechini¹  David M. Ojcius² 

[1] Universidade Federal do Rio de Janeiro (UFRJ)$$;University of California$$;Universidade Federal do Rio de Janeiro (UFRJ)$$University of California$$

关键词: purinergic receptors;   

DOI  :  10.1007/s11302-006-9039-6

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

A growing number of studies have demonstrated the importance of ATP_e-signalling via P2 receptors as an important component of the inflammatory response to infection. More recent studies have shown that ATP_e can also have a direct effect on infection by intracellular pathogens, by modulating membrane trafficking in cells that contain vacuoles that harbour intracellular pathogens, such as mycobacteria and chlamydiae. A conserved mechanism appears to be involved in controlling infection by both of these pathogens, as a role for phospholipase D in inducing fusion between lysosomes and the vacuoles has been demonstrated. Other P2-dependent mechanisms are most likely operative in the cases of pathogens, such as Leishmania, which survive in an acidic phagolysosomal-like compartment. ATP_e may function as a ‘danger signal–that alerts the immune system to the presence of intracellular pathogens that damage the host cell, while different intracellular pathogens have evolved enzymes or other mechanisms to inhibit ATP_e-mediated signalling, which should, thus, be viewed as virulence factors for these pathogens.

【 授权许可】

Unknown