Structure–activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors

Purinergic Signalling

José L. Boyer²  Maryse Picher¹  Roshni I. Patel²  Sammy R. Shaver²  William Pendergast²  Edward G. Brown²  Arthur C. Jones²  Benjamin R. Yerxa²  James G. Douglass²  Catherine C. Redick²  Janet L. Rideout² 

[1] University of North Carolina$$;Inspire$$

关键词: synthesis of dinucleotides;   

DOI  :  10.1007/s11302-005-0648-2

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Dinucleoside polyphosphates act as agonists on purinergic P2Y receptors to mediate a variety of cellular processes. Symmetrical, naturally occurring purine dinucleotides are found in most living cells and their actions are generally known. Unsymmetrical purine dinucleotides and all pyrimidine containing dinucleotides, however, are not as common and therefore their actions are not well understood. To carry out a thorough examination of the activities and specificities of these dinucleotides, a robust method of synthesis was developed to allow manipulation of either nucleoside of the dinucleotide as well as the phosphate chain lengths. Adenosine containing dinucleotides exhibit some level of activity on P2Y₁ while uridine containing dinucleotides have some level of agonist response on P2Y₂ and P2Y₆. The length of the linking phosphate chain determines a different specificity; diphosphates are most accurately mimicked by dinucleoside triphosphates and triphosphates most resemble dinucleoside tetraphosphates. The pharmacological activities and relative metabolic stabilities of these dinucleotides are reported with their potential therapeutic applications being discussed.

【 授权许可】

Unknown