P2X receptor-mediated purinergic sensory pathways to the spinal cord dorsal horn

Purinergic Signalling

Marc W. Heft¹  Jianguo G. Gu¹ 

[1] University of Florida$$

关键词: synaptic transmission ;   

DOI  :  10.1007/s11302-004-4743-6

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

P2X receptors are expressed on different functional groups of primary afferent fibers. P2X receptor-mediated sensory inputs can be either innocuous or nociceptive, depending on which dorsal horn regions receive these inputs. We provide a brief review of P2X receptor-mediated purinergic sensory pathways to different regions in the dorsal horn. These P2X purinergic pathways are identified in normal animals, which provides insights into their physiological functions. Future studies on P2X purinergic pathways in animal models of pathological conditions may provide insights on how P2X receptors play a role in pathological pain states.

【 授权许可】

Unknown