Antimicrobial xanthones from Garcinia mangostana L.

The Philippine Scientist

Garcia, Karla Divina¹  Ragasa, Consolacion¹  Shen, Chien-Chang¹  Crisostomo, Camille Joyce¹ 

关键词: Garcinia mangostana L.;    Guttiferae;    α-mangostin;    gartanin;    3-isomangostin;    antimicrobial;   

DOI  :  10.3860/psci.v47i0.2421

学科分类：自然科学（综合）

来源: San Carlos Publications

【 摘 要 】

The ethyl acetate extract of the freeze-dried pericarp of Garcinia mangostana L. afforded α-mangostin (1), gartanin (2) and a 2:1 mixture of 2 and 3-isomangostin (3) by silica gel chromatography. The structures of 1–3 were elucidated by extensive 1D and 2D NMR spectroscopy. At 30 μg, 1 exhibited high antibacterial activity against S. aureus, moderate activity against C. albicans, and low activity against B. subtilis, E. coli, P. aeruginosa, T. mentagrophytes, and A. niger. Compound 2 showed low antibacterial activity against E. coli, P. aeruginosa, S. aureus and B. subtilis, low antifungal activity against C. albicans and T. mentagrophytes, and was inactive against A. niger. A mixture of 2 and 3 exhibited low antibacterial activity against P. aeruginosa, S. aureus and B. subtilis, low antifungal activity against C. albicans and T. mentagrophytes, and was inactive against E. coli and A. niger.

【 授权许可】

Unknown