Analysis of intraspecific variation in venoms of Acanthophis antarcticus death adders from South Australia

Journal of Venom Research

A. Ian¹  Shane¹  Kai F.¹  Maxie¹  Volker¹  Wayne C.¹ 

关键词: Death adder;    Acanthophis antarcticus;    venom;    geographical and intraspecific variation;    chick biventer cervicis nerve-muscle preparation —————————————————————————————————————–;   

DOI  :  

学科分类：药理学

来源: Library Publishing Media

【 摘 要 】

Intraspecific variation in venom composition and activity has been reported from a wide range of snakes. Geographical origin can be one cause for this variation and has recently been documented from Acanthophis antarcticus death adders sampled across four different Australian states. The present study examined whether a narrower sampling range of A. antarcticus from four collection sites within one Australian state (i.e. South Australia) would also exhibit variation in venom composition and/or activity. The present LC-MS results reveal marked differences in the venom composition from different collection sites. The most striking difference was the reduced venom complexity found in the only venom originating from a mallee scrub habitat in comparison to the venoms from coastal heath scrub habitats. Interestingly, the pharmacological activity of all venoms was found to be the same, independent of the collection site.

【 授权许可】

Unknown