Implications of diagnosing ductal carcinoma in situ in core needle biopsies of the breast

Journal of Diagnostic Pathology

D Wijeyaratne²  M Lokuhetty¹  D Anthony³ 

[1] Department of Pathology, Faculty of Medicine, University of Colombo;Department of Pathology, Faculty of Medicine, University of Colombo, Sri Lanka and Department of Anatomical pathology, Queensland Medical Laboratory, Gold coast;Department of Anatomical pathology, Queensland Medical Laboratory, Gold coast

关键词: Carcinoma breast;    DCIS;    Core needle biopsy;    Breast conserving surgery;   

DOI  :  10.4038/jdp.v6i1.4419

学科分类：生理学与病理学

来源: College of Pathologists of Sri Lanka

【 摘 要 】

Objective: To study the implications of Ductal Carcinoma In Situ (DCIS) diagnosis in Core Needle Biopsies (CNBs) of the breast. Method:The histology slides of 59 CNBs and BCS (Breast conserving surgery) /Mastectomy were reviewed for the presence and percentage of DCIS and 63 BCS were reviewed for positivity of the surgical margins. SPSS -13 and appropriate statistical tests were used for analysis. Results: The sensitivity of CNB to predict DCIS in the surgical specimen was 45.65%. A positive relationship was established between DCIS positivity in CNB and DCIS percentage in the subsequent surgical specimen (p=0.002). A positive correlation exists between the number of positive margins and percentage of DCIS (p<0.01) in BCS specimens. The difference in the number of cores obtained was significant among the true DCIS positive and false negative cases (p=0.006). Conclusion: DCIS in CNB is often associated with DCIS in BCS/mastectomy in a higher percentage of the same. A higher percentage of DCIS frequently has positive BCS margins, thus wider excisions are indicated for women with DCIS positive CNB`s. Sensitivity of identifying DCIS in the CNB increases with number of CNB cores.DOI: http://dx.doi.org/10.4038/jdp.v6i1.4419 Journal of Diagnostic Pathology 2011(6); 1: 28-33 

【 授权许可】

Unknown