History, mechanisms and clinical value of fibrillation analyses in muscle denervation and reinnervation by Single Fiber Electromyography and Dynamic Echomyography

European Journal of Translational Myology

Amber Pond⁶  Francesco Piccione¹  Christian Hofer⁵  Sandra Zampieri⁷  Roberto Stramare²  Andrea Marcante⁴  Helmut Kern³  Leonora Martino²  Stefano Masiero⁴  Vincenzo Vindigni⁸  Riccardo Zanato² 

[1] Clinical Neurophysiology, San Camillo Hospital I.R.C.C.S., Venezia-Lido;CIR-Myo, Radiology, Department of Medicine, University of Padova;Department of Physical Medicine and Rehabilitation, Wilhelminenspital, Vienna;CIR-Myo, Rehabilitation and Physical Medicine Unit, Department of Neurosciences, University of Padova;Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna;Anatomy Department, Southern Illinois University School of Medicine, Carbondale, IL;CIR-Myo, Department of Biomedical Sciences, University of Padova;CIR-Myo, Plastic Surgery, Department of Neuroscience, University of Padova

关键词: keletal muscle;    denervation;    atrophy;    fibrillation;    clinical electromyography;    Single Fiber EMG (SFEMG);    dynamic echomyography (DyEM);   

DOI  :  10.4081/ejtm.2014.3297

学科分类：骨科学

来源: Pagepress

【 摘 要 】

This work reviews history, current clinical relevance and future of fibrillation, a functional marker of skeletal muscle denervated fibers. Fibrillations, i.e., spontaneous contraction, in denervated muscle were first described during the nineteenth century. It is known that alterations in membrane potential are responsible for the phenomenon and that they are related to changes in electrophysiological factors, cellular metabolism, cell turnover and gene expression. They are known to inhibit muscle atrophy to some degree and are used to diagnose neural injury and reinnervation that are occurring in patients. Electromyography (EMG) is useful in determining progress, prognosis and efficacy of therapeutic interventions and their eventual change. For patients with peripheral nerve injury, and thus without the option of volitional contractions, electrical muscle stimulation may be helpful in preserving the contractility and extensibility of denervated muscle tissue and in retarding/counteracting muscle atrophy. It is obvious from the paucity of recent literature that research in this area has declined over the years. This is likely a consequence of the decrease in funding available for research and the fact that the fibrillations do not appear to cause serious health issues. Nonetheless, further exploration of them as diagnostic tools in long-term denervation is merited, in particular if Single Fiber EMG (SFEMG) is combined with Dynamic Echomyography (DyEM), an Ultra Sound muscle approach we recently designed and developed to explore denervated and reinnervating muscles.

【 授权许可】

Unknown