Impact of long-term use of oral nutritional supplement on nutritional adequacy, dietary diversity, food intake and growth of Filipino preschool children

Journal of Nutritional Science

Maria Rosario Capeding¹  Dieu T. T. Huynh²  Jeffery S. Oliver³  Yen Ling Low²  Elvira Estorninos¹  Francisco J. Rosales³ 

[1] Asian Hospital and Medical Centre;Abbott Nutrition Research & Development;Scientific and Medical Affairs

关键词: Long-term supplementation;    Oral nutritional supplementation;    Nutritional adequacy;    Dietary diversity;    Longitudinal growth;   

DOI  :  10.1017/jns.2016.6

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Using a sequential in vitro/in vivo approach, we tested the ability of botanical extracts to influence biomarkers associated with bone resorption and bone formation. Pomegranate fruit and grape seed extracts were found to exhibit anti-resorptive activity by inhibiting receptor activator of nuclear factor-κB ligand (RANKL) expression in MG-63 cells and to reduce IL-1β-stimulated calvarial 45Ca loss. A combination of pomegranate fruit and grape seed extracts were shown to be effective at inhibiting bone loss in ovariectomised rats as demonstrated by standard histomorphometry, biomechanical and bone mineral density measurements. Quercetin and licorice extract exhibited bone formation activity as measured by bone morphogenetic protein-2 (BMP-2) promoter activation, increased expression of BMP-2 mRNA and protein levels, and promotion of bone growth in cultured mouse calvariae. A combination of quercetin and licorice extract demonstrated a potential for increasing bone mineral density in an intact female rat model as compared with controls. The results from this sequential in vitro/in vivo research model yielded botanical extract formulas that demonstrate significant potential benefits for bone health.

【 授权许可】

Unknown