Serum Bilirubin Links UGT1A1*28 Polymorphism and Predicts Long-Term Cardiovascular Events and Mortality in Chronic Hemodialysis Patients

Journal of the American Society of Nephrology

Szu-Chun Hung¹  Der-Cherng Tarng¹  Ying-Hwa Chen¹ 

关键词: Bone marrow necrosis;    Sickle cell disease;    Hyperhemolysis syndrome;   

DOI  :  10.2215/CJN.06130710

学科分类：泌尿医学

来源: American Society of Nephrology

【 摘 要 】

Background and objectives Bilirubin is a protective factor with antioxidant and anti-inflammatory properties, but its association with clinical outcomes of hemodialysis patients is unknown. Bilirubin degradation is mainly determined by the activity of hepatic bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1), which is significantly influenced by a TA-repeat polymorphism in the gene's promoter, an allele designated UGT1A1*28. The study aimed to clarify the association between serum bilirubin and UGT1A1*28 polymorphism and their respective effect on outcomes of chronic hemodialysis patients.

【 授权许可】

Unknown