Robust and Optimal Control of Magnetic Microparticles inside Fluidic Channels with Time-Varying Flow Rates

International Journal of Advanced Robotic Systems

Islam S.M. Khalil¹  Mostafa Shoukry¹  Rasha M. El-Nashar¹  Sarthak Misra¹  Hazem Abass¹  Mohamed Serry¹  Anke Klingner¹ 

关键词: Time-varying Flow;    Magnetic;    Microfluidic Channel;    Microparticles;    Disturbance;    Optimal Control;   

DOI  :  10.5772/63517

学科分类：自动化工程

来源: InTech

【 摘 要 】

Targeted therapy using magnetic microparticles and nanoparticles has the potential to mitigate the negative side-effects associated with conventional medical treatment. Major technological challenges still need to be addressed in order to translate these particles into in vivo applications. For example, magnetic particles need to be navigated controllably in vessels against flowing streams of body fluid. This paper describes the motion control of paramagnetic microparticles in the flowing streams of fluidic channels with time-varying flow rates (maximum flow is 35 ml.hr−1). This control is designed using a magnetic-based proportional-derivative (PD) control system to compensate for the time-varying flow inside the channels (with width and depth of 2 mm and 1.5 mm, respectively). First, we achieve point-to-point motion control against and along flow rates of 4 ml.hr−1, 6 ml.hr−1, 17 ml.hr−1, and 35 ml.hr−1. The average speeds of single microparticle (with average diameter of 100 μm) against flow rates of 6...

【 授权许可】

Unknown