One year in review 2016: Behçet’s syndrome

Clinical and Experimental Rheumatology

  Authors: Gulen Hatemi¹  Rosaria Talarico¹  Emire Seyahi¹  Izzet Fresko¹  Vedat Hamuryudan¹ 

关键词: Behçet’s syndrome;    pathogenesis;    outcome assessment;    therapeutics;    disease management;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic synovial inflammation leading to joint destruction and bone erosions. Although the pathogenic mechanisms underlying the disease are not fully elucidated, it is known that genetic susceptibility and environmental factors trigger an abnormal autoimmune response. Potentially, any organ and tissue could be affected by RA and the increased cardiovascular (CV) risk represents the major complication responsible for a worse prognosis. In this setting, the shared pathogenic mechanisms between RA pathogenesis and accelerated atherosclerosis further strengthen the rationale for a treat-to-target strategy with synthetic and biologic disease modifying anti-rheumatic drugs. The aim of this review is to provide the novel insights, regarding the pathogenesis of RA, published over the last year.

【 授权许可】

Unknown