Resetting the immune system with immunoablation and autologous haematopoietic stem cell transplantation in autoimmune diseases

Clinical and Experimental Rheumatology

Tobias Alexander¹  Andreas Radbruch¹  Falk Hiepe¹  Renate Arnold¹ 

关键词: Stem cell transplantation;    autoimmune diseases;    autologous hematopoietic stem cells transept (ASCT);    immune reset;    immune reconstitution;    Autoimmune diseases;    stem cell transplantation;    autologous hematopoietic stem cells transept (ASCT);   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

B lymphocytes provide essential mechanisms of protection against infectious diseases. The secretion of specific antibodies by long-lived plasma cells is thought to account for the improved resistance afforded by most successful vaccines against pathogens. Accordingly, a goal in vaccine development is to induce potent B cell responses in order to drive the efficient formation of long-lived antibody-secreting cells. However, the roles of activated B cells are complex in infectious diseases. It was recently observed that activated B cells could also negatively regulate host defence mechanisms, both during primary infection and, after vaccination, upon secondary challenge, via mechanisms involving their production of the anti-inflammatory cytokines interleukin (IL)-10 and IL-35. Remarkably, the B cells expressing IL-10 and IL-35 in vivo were distinct subsets of IgMhiCD19+CD138hi antibody-secreting cells. A better understanding of the diverse roles of these distinct antibody-secreting cell subsets in immunity and immunological memory, as well as of the signals controlling their generation, might help the rational development of better prophylactic and therapeutic vaccines.

【 授权许可】

Unknown