Role of IL-17A signalling in psoriasis and associated bone loss

Clinical and Experimental Rheumatology

Özge Uluçkan¹  Erwin F. Wagner¹ 

关键词: Psoriasis;    IL-17A;    bone loss;    skin inflammation;    osteoblast;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

Psoriatic arthritis (PsA) is a clinically heterogeneous condition of skin, joint, enthesis and bone that provides considerable unmet therapeutic need. Recent treatment advances have offered new opportunities to improve quality of life and long term well being for afflicted patients. It is timely therefore, to consider the underlying heterogeneity inherent in the disease from a pathologic aspect so as to best optimise the choice and order of therapeutic application over time. Herein I will discuss the various contributions made by immune pathways to discrete tissue compartments that in turn might allow a more targeted approach to the management of PsA in which different tissues express variable severity of involvement.

【 授权许可】

Unknown