Interleukin-12 and interleukin-23 inhibition in psoriatic arthritis

Clinical and Experimental Rheumatology

  Authors: Hanna J. Johnsson¹  Iain B. McInnes¹ 

关键词: Psoriatic arthritis;    ustekinumab;    psoriasis;    interleukin-23;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

The cytokines interleukin (IL)-12 and interleukin (IL)-23 have been implicated variously in the pathogenesis of psoriasis and psoriatic arthritis (PsA). By corollary, the IL-12/23 inhibitor, Ustekinumab has been developed as an approved therapeutic for the skin and musculoskeletal syndrome of psoriasis / PsA. This review describes briefly the role of IL-12 and IL-23 in the pathophysiology of psoriatic arthritis and evaluates trial data that support its clinical use in psoriasis and different manifestations of psoriatic arthritis. The next steps towards targeting this pathway also are discussed.

【 授权许可】

Unknown