Environments of hematopoiesis and B-lymphopoiesis in foetal liver

Clinical and Experimental Rheumatology

Fritz Melchers¹  Motokazu Tsuneto¹  Katja Kajikhina¹ 

关键词: Foetal liver;    Hematopoiesis;    mMigration;    B-lymphopoiesis;    Stromal cell niches;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

In human and murine embryonic development, haematopoiesis and B-lymphopoiesis show stepwise differentiation from pluripotent haematopoietic stem cells and multipotent progenitors, over lineage-restricted lymphoid and myeloid progenitors to B-lineage committed precursors and finally differentiated pro/preB cells. This wave of differentiation is spatially and temporally organised by the surrounding, mostly non-haematopoietic cell niches. We review here recent developments and our current contributions on the research on blood cell development.

【 授权许可】

Unknown