Clinical and Experimental Rheumatology | |
Selection of natural autoreactive B cells | |
Kyoko Hayakawa1  Richard R. Hardy1  | |
关键词: Autoreactivity; natural autoantibody; B cell selection; anti-thymocyte autoantibody; CD5+ B cell; B1 B cell; B cell development; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
【 摘 要 】
Natural antibodies produced by CD5+ B1 B cells include anti-thymocyte autoantibody (ATA). Transgenic mice bearing the Ig-μ heavy chain of a prototypic ATA, VH3609Vκ21c, demonstrated a critical requirement for self-antigen in the accumulation of ATA B cells and production of high levels of serum ATA. Further work with ATA-μκ transgenic mice revealed that, while development of most B cells were blocked at an immature stage in spleen, some mature ATA B cells were present. ATA-μκ transgenic mice with varying levels of Thy-1 autoantigen showed a clear relationship between BCR crosslinking and B cell fate, with low levels generating marginal zone ATA B cells and complete antigen absence allowing maturation to follicular ATA B cells. Finally, different fates of developing ATA B cells encountering high levels self-antigen may be accounted for by variations in the response of newly formed B cells arising from foetal and adult development.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020417608ZK.pdf | 2980KB | download |