Insular cortex is a trait marker for pain processing in fibromyalgia syndrome - blood oxygenation level-dependent functional magnetic resonance imaging study in Korea

Clinical and Experimental Rheumatology

Seong-Ho Kim¹  Seung Jae Lee¹  Sang-Hyon Kim¹  Jeehye Seo¹  Yongmin Chang¹  Eon Jeong Nam¹  Tae Young Choi¹  Hui-jin Song¹  Seong-Kyu Kim¹  Joo-hyun Kim¹  Seung Woo Han¹ 

关键词: Fibromyalgia;    pain;    insula;    blood oxygen level dependent;    functional magnetic resonance imaging;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: To investigate the variability in cerebral activation according to pain intensity and the association between variability in cerebral activation and clinical features in patients with fibromyalgia syndrome (FMS) using functional magnetic resonance imaging (fMRI). METHODS: Nineteen FMS female patients and 22 age-matched healthy female controls were enrolled in this study. Changes in cerebral activation area were measured using blood oxygenation level-dependent (BOLD) contrast fMRI after application of both medium and high pressure stimuli to the left thumbnail bed. RESULTS: We identified the insular cortex (IC) and superior temporal gyrus (STG) as regions of interest (ROIs) in this analysis. Cerebral activation at the bilateral IC in response to high pressure stimuli was significantly greater in FMS patients than it was in the controls, whereas there were no differences in BOLD signal changes in the STG regions between FMS patients and controls, irrespective of pain level. Prominent signal changes at both ROIs in FMS patients were noted between high and medium pressure (p

【 授权许可】

Unknown