Clinical and Experimental Rheumatology | |
Association of mannose-binding lectin 2 gene polymorphic variants with susceptibility and clinical progression in systemic lupus erythematosus | |
Vanessa S. Mattevi1  Ricardo M. Xavier1  Bruno P. dos Santos1  Nadine Glesse1  Guilherme G. Rucatti1  Odirlei A. Monticielo1  Gabriela K. da Silva1  José A.B. Chies1  Joao C.T. Brenol1  | |
关键词: Systemic lupus erythematosus; mannose-binding lectin; polymorphism; complement system proteins; Mannose-binding lectin; SLE; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
【 摘 要 】
OBJECTIVES: This study investigates the role of mannose-binding lectin (MBL) in susceptibility and clinical expression of systemic lupus erythematosus (SLE), through the analysis of promoter region and exon 1 polymorphisms of the MBL2 gene. METHODS: We analysed 325 SLE patients from the Hospital de ClÃnicas de Porto Alegre and 344 controls. All individuals were grouped according to ethnic origin. Genotyping of the promoter and exon 1 variants were performed by PCR-SSP and PCR-RFLP, respectively. Polymorphisms frequencies between patients and controls were compared by Chi-square or Fisher`s exact tests. RESULTS: A statistically significant difference was observed among the frequencies of both promoter haplotypes (p=0.005) and haplotypic combinations (p=0.004) in African-derived patients, with a higher incidence of HY haplotype and LY/HY combination in SLE patients when compared to controls. These results showed a tendency to higher frequencies of genotypes related to high MBL levels in African-derived patients. A joint analysis of data from the promoter and exon 1 polymorphisms showed an increased frequency of genotypes conferring a deficient of MBL levels in European-derived patients (p
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020417333ZK.pdf | 179KB | download |