Clinical and Experimental Rheumatology | |
Glucocorticoids in rheumatoid arthritis: lessons from the Utrecht study | |
J.W.J. Bijlsma1  J.W.G. Jacobs1  | |
关键词: Glucocorticoid; therapy; treatment; rheumatoid arthritis; prednisolone; radiological joint damage; disease modifying effect; Rheumatoid arthritis; glucocorticoid; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
【 摘 要 】
The lessons from the Utrecht study on glucocorticoid therapy in early rheumatoid arthritis and of the spin-off and follow-up studies are reviewed. The data indicate that: glucocorticoids are DMARDs, the joint-sparing effect is predominantly on erosions, glucocorticoids do not influence the percentage of patients developing erosive disease, and the gain in joint-sparing effect persists after the stop of treatment. Further lessons are that the size of the joint-sparing effect and the (presumed) size of the symptomatic effect of glucocorticoids depend on co-therapies. Additional DMARDs must be added to glucocorticoids for maximum effect on radiographic progression. Finally, low-dose glucocorticoids are safer than often thought.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020417308ZK.pdf | 648KB | download |