Microparticles and Kawasaki disease: a marker of vascular damage?

Clinical and Experimental Rheumatology

Fernanda Falcini¹  Laura Ricci¹  Irene Miniati¹  Claudia Ceccarelli¹  Jorg H.W. Distler¹  Giovanni Battista Calabri¹  Marco Matucci Cerinic¹  Eloisa Romano¹  Oliver Distler¹  Serena Guiducci¹ 

关键词: Kawasaki disease;    microparticles;    Microparticles;    Kawasaki disease;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

BACKGROUND: Microparticles (MPs) are increased in diseases characterised by endothelial injury. Kawasaki disease (KD) damages the endothelium provoking life-threatening involvement of coronary arteries. OBJECTIVES: To compare KD MPs vs. controls. METHODS. Thirty KD and 20 controls were enrolled. MPs were stained with monoclonal antibodies against platelets, endothelial cells (EC), monocytes, T and B cells, neutrophils, and quantified by FACS. RESULTS: The total number of MPs was significantly increased in KD versus controls (193x105±0.6x105 vs. 94x105±0.9x105 million/ml plasma p=0.01) and vs. KD after IVIG therapy (132x105±0.4x105million/ml plasma p=0.01). EC and T cells were the major source of MPs in KD (72x105±1x105 vs. 3x105±0.9x105million/ml plasma for T cells p=0.005; 76x105±0.7x105 vs. 45x105±0.4x105 million/ml plasma for EC p

【 授权许可】

Unknown