The presence of autoimmune thyroiditis in mixed cryoglobulinemia patients is associated with high levels of circulating Interleukin-6, but not of tumor necrosis factor-alpha

Clinical and Experimental Rheumatology

Andrea Di Domenicantonio¹  Cinzia Pupilli¹  Santino Marchi¹  Clodoveo Ferri¹  Paola Ferrari¹  Silvia Martina Ferrari¹  Poupak Fallahi¹  andrea nicolini¹  Anna Linda Zignego¹  Alessandro Antonelli¹ 

关键词: IL-6;    autoimmune thyroid disorders;    TNF-alpha;    autoimmune thyroid disorders;    cryoglobulinemia;    chemokines.;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: To our knowledge, no study has evaluated serum levels of interleukin-6 (IL-6), together with tumour necrosis factor-alpha (TNF-α), in a large series of patients with `mixed cryoglobulinemia and HCV chronic infection` (MC+HCV) in relation to the presence of autoimmune thyroiditis (AT). The aims of the study were to evaluate serum levels of IL-6 in MC+HCV patients and to correlate this parameter with the presence of AT and with circulating levels of TNF-α. METHODS: Serum IL-6 and TNF-α were assayed in 41 MC+HCV patients, in 41 MC+HCV patients with autoimmune thyroiditis (MC+AT), in 41 sex- and age-matched controls, and 20 AT patients. RESULTS: MC+HCV patients showed significantly (p

【 授权许可】

Unknown