期刊论文详细信息
Clinical and Experimental Rheumatology
The presence of autoimmune thyroiditis in mixed cryoglobulinemia patients is associated with high levels of circulating Interleukin-6, but not of tumor necrosis factor-alpha
Andrea Di Domenicantonio1  Cinzia Pupilli1  Santino Marchi1  Clodoveo Ferri1  Paola Ferrari1  Silvia Martina Ferrari1  Poupak Fallahi1  andrea nicolini1  Anna Linda Zignego1  Alessandro Antonelli1 
关键词: IL-6;    autoimmune thyroid disorders;    TNF-alpha;    autoimmune thyroid disorders;    cryoglobulinemia;    chemokines.;   
DOI  :  
学科分类:医学(综合)
来源: Pacini Editore SpA
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【 摘 要 】

OBJECTIVES: To our knowledge, no study has evaluated serum levels of interleukin-6 (IL-6), together with tumour necrosis factor-alpha (TNF-α), in a large series of patients with `mixed cryoglobulinemia and HCV chronic infection` (MC+HCV) in relation to the presence of autoimmune thyroiditis (AT). The aims of the study were to evaluate serum levels of IL-6 in MC+HCV patients and to correlate this parameter with the presence of AT and with circulating levels of TNF-α. METHODS: Serum IL-6 and TNF-α were assayed in 41 MC+HCV patients, in 41 MC+HCV patients with autoimmune thyroiditis (MC+AT), in 41 sex- and age-matched controls, and 20 AT patients. RESULTS: MC+HCV patients showed significantly (p

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