Arterial stiffness and proinflammatory cytokines in fibromyalgia syndrome

Clinical and Experimental Rheumatology

Jung-Yoon Choe¹  Young Soo Lee¹  Seong-Kyu Kim¹  Kee Sik Kim¹  Sung-Hoon Park¹ 

关键词: fibromyalgia syndrome;    pulse wave velocity;    augmentation index;    arterial stiffness;    interleukin-8;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: We assessed arterial stiffness and inflammatory cytokine profiles in fibromyalgia syndrome (FMS) patients and analysed the association between them. METHODS: Twenty-seven FMS patients and 29 age-matched premenopausal healthy controls were enrolled in this study. Arterial stiffness was assessed by pulse wave velocity (PWV) and augmentation index (AIx) from pulse waveform analysis. Levels of serum interleukin-1β (IL-1β), IL-6, IL-8, and vascular endothelial growth factor (VEGF) were measured by enzymelinked immunosorbent assay, and a colorimetric assay was used for measurement of serum nitric oxide (NO) metabolites (nitrate and nitrite, NOx) level. Statistical analyses included the Mann-Whitney U-test and Spearman`s correlation coefficient analysis. RESULTS: Higher AIx and AIx@HR75 (aortic AIx at a heart rate of 75beats/min) were noted in FMS compared to those in the controls after adjustment using covariants (padj=0.023 and padj0.05 for all). FMS subjects had significantly higher serum IL-8 levels than did the healthy controls (327.9±588.7 vs. 76.4±90.5, padj=0.041). However, there were no significant differences in serum IL-1β, IL-6, VEGF, or NOx levels between the FMS patients and the controls (padj>0.05 of all). Serum IL-8 level did not correlate with PWV and AIx in FMS patients. CONCLUSIONS: This study demonstrates higher AIx and IL-8 levels in FMS subjects compared to those of the controls. However, arterial stiffness including AIx in FMS was not determined by the serum IL-8 level.

【 授权许可】

Unknown