A follow-up study of patients with juvenile idiopathic arthritis who discontinued etanercept due to disease remission

Clinical and Experimental Rheumatology

Polyxeni Pratsidou-Gertsi¹  Florence Kanakoudi-Tsakalidou¹  Grigoris Pardalos¹  Maria Trachana¹ 

关键词: juvenile idiopathic arthritis;    anti-TNF;    etanercept;    outcome;    Juvenile Arthritis Disease Activity Score;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: Assessment of the post-etanercept (ET) disease course in patients with juvenile idiopathic arthritis (JIA) who discontinued the drug due to disease remission, using a recently developed tool that scores the disease activity. METHODS: Eleven patients (F/M 9/2, median age 9.2 years), with either a polyarthritis` (9) or an oligoarthritis` (2) disease course were followed up for 12.25–27 months after ET withdrawal. The median treatment period under ET was 36 months. The Juvenile Arthritis Disease Activity Score (JADAS) was used to grade the JIA activity at the time of ET commencement, at discontinuation and at the time of the flare. RESULTS: All 11 patients flared during the follow-up period. Compared to the time of ET initiation, JADAS was significantly reduced at ET discontinuation as well as at the time of the flare (26.3 to 0 and to 9.5 respectively, p

【 授权许可】

Unknown