How does methotrexate suppress inflammation?

Clinical and Experimental Rheumatology

Bruce Cronstein¹ 

关键词: Adenosine;    methotrexate;    inflammation;    purine metabolism;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

Methotrexate remains the most widely used agent for the treatment of rheumatoid arthritis and other chronic inflammatory diseases. Although introduced as a chemotherapeutic agent for the treatment of malignancies, it is clear that, in the doses used, the mechanism of action in the suppression of inflammation differs from simply suppression of purine and pyrimidine metabolism, resulting in inhibition of proliferation. Here we review the proposed mechanisms of action of methotrexate.

【 授权许可】

Unknown