Decreased levels of CCR3 in CD4+ lymphocytes of rheumatoid arthritis patients

Clinical and Experimental Rheumatology

Jacob N. Ablin¹  Sofia Maysel-Auslender¹  Valerie Aloush¹  Shirly Oren¹  Ori Elkayam¹  Jacob George¹  Michal Entin-Meer¹  Irena Wigler¹ 

关键词: Rheumatoid arthritis;    CCR3 receptors;    Eotaxin-2;    RANTES;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: To evaluate the expression of CCR3 receptors as well as CCR3 agonists, including eotaxin-2 and RANTES, among patients suffering from rheumatoid arthritis and healthy controls, as a possible pathogenetic mechanism in inflammatory joint disease. METHODS: Twenty-two patients and 13 healthy controls were recruited and clinically evaluated. CCR3 expression on CD4+ lymphocytes and mononuclear cells was evaluated by FACS analysis after staining with human CD4 APC (bioscience) and human CCR3 (CD193)PE. Levels of eotaxin-2 and RANTES were analysed by ELISA. RESULTS: A significant decrease was observed in the level of CD4+ cells expressing the CCR3 receptor in serum of RA patients (0.96±0.5) as compared with healthy controls (1.48±0.6) (p

【 授权许可】

Unknown