Clinical and Experimental Rheumatology | |
Association of HLA DRB1 alleles with Juvenile Idiopathic Arthritis in Mexicans. | |
Gilberto Vargas-Alarcón1  Beatriz Silva-Ramirez1  Nadina Rubio-Perez1  Ruben Burgos-Vargas1  Julio Granados-Arriola1  Nonanzit Perez-Hernandez1  Ricardo Cerda-Flores1  | |
关键词: Juvenile Idiopathic Arthritis. HLA-DRB1. Molecular class II analysis.; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
【 摘 要 】
OBJECTIVES:The aim of the study was to investigate association between HLA class II alleles and juvenile idiopathic arthritis (JIA) in Mexican patients.PATIENTS AND METHODS: We typed 120 patients with JIA and 99 healthy controls for HLA class II alleles were performed by PCR-SSO. Differences between the whole group of JIA and its subtypes and controls were calculated by using the &Xgr;2; p-values were corrected (pc) with Bonferroni`s test. RESULTS:The alleles HLA-DRB1*01 (pc= 0.00083) and HLA-DRB1*04 (pc=0.0049) were strongly associated with systemic JIA, while HLA-DRB1*11 and HLA-DRB1*14 were found to have decreased frequencies in the patients with systemic JIA compared to the controls. Two alleles were found to have increased frequencies with JIA oligoarthritis subgroup, HLA-DRB1*11 (p=0.01, pc=NS) and HLA-DRB1*13 (p=0.01, pc=NS). The HLA-DRB1*04 was found increased frequencies with susceptibility for RF negative and RF positive polyarthritis JIA subgroups (p correction resulted in loss of significance). In contrast two alleles HLA-DRB1*07 and HLA-DRB1*14 were found decreased frequencies only patients RF positive polyarthritis JIA subgroup compared to the controls (pc=NS). CONCLUSIONS:The profile of HLA-DRB1 alleles associations in Mexican with JIA were somewhat distinct from association typically found in Caucasians.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020416875ZK.pdf | 139KB | download |