Safety and potential efficacy of tacrolimus for treatment of lupus nephritis with persistent proteinuria

Clinical and Experimental Rheumatology

Isao Furugo¹  Takahiko Horiuchi¹  Terufumi Shimoda¹  Hiroki Mitoma¹  Ayumi Uchino¹  Hiroshi Tsukamoto¹  Yoshifumi Tada¹  Hitoshi Nakashima¹  Koichi Akashi¹  Takahisa Yano¹  Seiji Yoshizawa¹  Hiroaki Niiro¹  Ryozo Oishi¹  Kensuke Oryoji¹  Toshiharu Nonaka¹ 

关键词: Lupus nephritis;    maintenance therapy;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES:To evaluate the safety and potential efficacy of tacrolimus for the treatment of patients with lupus nephritis and persistent proteinuria.METHODS:A total of 23 Japanese patients with lupus nephritis (21 females / 2 males) were enrolled in this study. Patients were administered tacrolimus at a dose of 2-3 mg once daily after the evening meal for 6 months. The dose of tacrolimus was unchanged throughout the study period. Concomitant prednisolone therapy was unchanged or gradually tapered, while other immunosuppressants were stopped at the start of tacrolimus treatment.RESULTS:Tacrolimus was well tolerated, and none of the patients developed adverse drug reactions that required discontinuation of the study. Daily urinary protein loss, the U-prot/U-creat ratio, and serum albumin were significantly improved after 4 months, 3 months, and 1 month of treatment with tacrolimus (p

【 授权许可】

Unknown