Induction of psoriatic skin lesions in a patient with rheumatoid arthritis treated with rituximab

Clinical and Experimental Rheumatology

Alexandros A. Drosos¹  Theodora E. Markatseli¹  Paraskevi V. Voulgari¹  Aikaterini Zioga¹  Evripidis S. Kaltsonoudis¹ 

关键词: Rheumatoid arthritis;    rituximab;    psoriasis;    autoimmune phenomena;    Rituximab;    rheumatoid arthritis;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

ABSTRACT:Rituximab is a chimeric monoclonal therapeutic antibody which causes depletion of CD20-positive B cells. Apart from its apparent efficacy in the treatment of non-Hodgkin lymphoma and of several rheumatic diseases, it is associated with adverse events including the induction of autoimmune phenomena. We describe here the development of psoriatic skin lesions in a patient with rheumatoid arthritis after the second course of treatment with rituximab. This report supports the hypothesis that autoimmune phenomena may occur by biologic agents and there is a link between B-cell depletion and the induction of psoriatic skin lesions, which were confirmed histologically. However, further studies are needed in order to identify the underlying mechanism, as well as the risk factors associated with rituximab-induced psoriatic skin lesions.

【 授权许可】

Unknown