Urate oxidase (rasburicase) for treatment of severe acutegout: a case report

Clinical and Experimental Rheumatology

Michael Schirmer¹  Christina Duftner¹  Markus Gaugg¹  Christian Dejaco¹  Edith Wipfler-Freißmuth¹  Michaela Kriessmayr-Lungkofler¹ 

关键词: Gout;    renal insufficiency;    urate oxidase;    Renal insufficiency&gout;    Urate oxidase;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

A 73-year-old female patient was referred to our department because of gouty arthritis in the right first toe. The patient suffered from progressive renal failure because of pauci-immune necrotising glomerulonephritis. As severe hyperuricaemia would further worsen progredient renal insufficiency and therapy with allopurinol was contraindicated because of renal insufficiency and previous pancytopenia, the patient was treated twice with intravenous rasburicase. This therapy was well tolerated by the patient and led to the decrease of serum uric acid below the detection limit within 24 hours.

【 授权许可】

Unknown