Rheumatoid arthritis, Klippel-Feil's syndrome and Pott's disease in Cardinal Carlo de' Medici (1595-1666)

Clinical and Experimental Rheumatology

Davide Caramella¹  Antonio Fornaciari¹  Sara Giusiani¹  Angelica Vitiello¹  Natale Villari¹  Gino Fornaciari¹  Valentina Giuffra¹ 

关键词: Rheumatoid arthritis;    ankylosis;    tuberculosis;    Medici;    Florence;    Renaissance;    Medici;    Renaissance;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: A paleopathological study was carried out on the skeletal remains of Cardinal Carlo de` Medici (1595-1666), son of the Grand Duke Ferdinando I (1549-1609) and Cristina from Lorraine (1565-1636), to investigate the articular pathology described in the archival sources. METHODS: The skeletal remains of Carlo, buried in the Basilica of San Lorenzo in Florence, have been exhumed and submitted to macroscopic and radiological examination. RESULTS: The skeleton of Carlo revealed a concentration of different severe pathologies. Ankylosis of the cervical column, associated with other facial and spine anomalies suggests a diagnosis of congenital disease: the Klippel-Feil syndrome. In addition, the cervical segment presents the results of the tuberculosis (Pott`s disease) from which the Cardinal suffered in his infancy. The post-cranial skeleton shows an ankylosing disease, mainly symmetrical and extremely severe, involving the large as well as small articulations, and characterized by massive joint fusion, that totally disabled the Cardinal in his last years of life. CONCLUSIONS: The final diagnosis suggests an advanced, ankylosing stage of rheumatoid arthritis.

【 授权许可】

Unknown