Clinical and Experimental Rheumatology | |
Anti-cyclic citrullinated peptide antibody in systemic sclerosis | |
Y. Muro1  Y. Tomita1  K. Sugiura1  Y. Morita1  | |
关键词: Anti-cyclic citrullinated peptide antibody; overlap syndrome; rheumatoid arthritis; systemic sclerosis.; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
【 摘 要 】
OBJECTIVES:To determine if anti-cyclic citrullinated peptide (anti-CCP) antibody titers can distinguish the overlap syndrome of systemic sclerosis and rheumatoid arthritis (SSc-RA) in patients with systemic sclerosis (SSc) and to investigate the clinical significance of anti-CCP antibodies in SSc.METHODS:Serum levels of anti-CCP antibodies were measured by enzyme-linked immunosorbent assay in 159 outpatients: 114 with SSc, 14 with rheumatoid arthritis, 7 with SSc-RA overlap syndrome, and 24 with Sjögren`s syndrome. In patients with SSc and SSc-RA, we also measured serum levels of matrix metalloproteinase-3 and anti-agalactosyl IgG antibody.RESULTS:Elevated serum levels of anti-CCP antibodies were observed in 3 of 114 patients (2.6%) with SSc, 9 of 14 patients (64%) with RA, 6 of 7 patients (86%) with SSc-RA, and only 1 of 24 patients (4.2%) with SjS. In patients with SSc-RA, serum anti-CCP antibody levels were significantly higher than those seen in SSc (p<0.001). The sensitivity, specificity, and predictive values of elevated anti-CCP titers for SSc-RA were higher than either matrix metalloproteinase-3 and anti-agalactosyl IgG antibodies as markers. In addition, almost all SSc-RA and SSc patients with elevated serum levels of anti-CCP antibodies exhibited arthralgias and interstitial pneumonia.CONCLUSIONS:Anti-CCP antibody titers are a reliable marker of SSc-RA facilitating its distinction from SSc alone.
【 授权许可】
Unknown
【 预 览 】
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RO201912020416431ZK.pdf | 283KB | download |