Osteomalacia revealing cœliac disease and primary biliary cirrhosis-related Fanconi syndrome in a patient with systemic sclerosis

Clinical and Experimental Rheumatology

B. Terrier¹  M.-A. Bouldouyre¹  F. Fakhouri¹  L. Guillevin¹  B. Terris¹  L. Mouthon¹  L.-H. Noël¹  P. Sogni¹  A. Berezne¹  P. Guilpain¹ 

关键词: Osteomalacia;    systemic sclerosis;    cœliac disease;    primary biliary cirrhosis;    Fanconi syndrome;    tubulointerstitial nephritis.;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

ABSTRACT: Systemic sclerosis (SSc) may affect the gastrointestinal tract and cause very rarely malabsorption syndrome related to bacterial overgrowth. Malabsorption syndrome may be responsible for weight loss, diarrhea, osteomalacia, and iron and vitamins deficiency. We report the case of a SSc patient who developed osteomalacia caused by the combination of two exceptional conditions in the setting of SSc: celiac disease (CD) and primary biliary cirrhosis (PBC)-related Fanconi syndrome. Oral prednisone with angiotensin-converting enzyme inhibitors, was initiated because of active lesions of tubulitis, and led to the complete regression of bone pains, and by the improvement of renal function and regression of the features of proximal tubulopathy. Thus, in the presence of vitamin deficiencies in a patient with SSc, together with a search for malabsorption syndrome secondary to bacterial overgrowth, CD and/or PBC-associated Fanconi syndrome should be investigated.

【 授权许可】

Unknown