期刊论文详细信息
Clinical and Experimental Rheumatology | |
The programmed cell death 1 gene 7209 C>T polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population | |
M. Mostowska1  H. Chwalińska-Sadowska1  M. Wudarski1  P.P. Jagodziński1  | |
关键词: PDCD1; systemic lupus erythematosus; polymorphism.; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
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【 摘 要 】
ABSTRACT: Numerous investigations indicated that the programmed cell death 1 (PDCD1) gene polymorphisms contribute to the development of systemic lupus erythematosus (SLE). However, their association with SLE has been found to be controversial. Therefore, in patients with SLE (n=102) and controls (n=140) we examined the association of six polymorphisms of this gene with susceptibility to SLE in the Polish population. We found that PDCD1 7209 CT or 7209 TT genotype exhibited 3.282-fold increased risk of SLE (95% CI=1.553 – 6.935; p=0.0017). The allele and genotype frequencies of the remaining polymorphisms: 5708 C>T, 6438 G>A, 7146 G>A and 8737 G>A did not exhibit statistical differences between SLE patients and controls. Our results confirmed the association of 7209 C>T polymorphism of PDCD1 gene with SLE that was previously observed in the Taiwanese population.【 授权许可】
Unknown
【 预 览 】
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RO201912020416386ZK.pdf | 176KB | ![]() |