Tumor necrosis factor-α and interleukin-4 gene polymorphisms in Chinese patients with gout

Clinical and Experimental Rheumatology

F.-J. Tsai¹  M.-L. Chen¹  C.-M. Huang¹  C.-H. Tsai¹ 

关键词: IL-4;    TNF-α;    gout;    gene polymorphism.;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES:The purpose of this study was to examine whether polymorphisms of interleukin-4 (IL-4) (promoter-590 and intron 3) and tumor necrosis factor-α (TNF-α) promoter-308 genes are markers of susceptibility to or clinical manifestations of gout in Taiwanese patients.METHODS:The study included 196 Taiwanese patients with gout and 103 unrelated healthy control subjects living in central Taiwan. Polymorphisms of the IL-4 (promoter-590 and intron 3) and TNF-α (promoter-308) genes were typed from genomic DNA. Allelic frequencies and carriage rates were then compared between gout patients and control subjects. The correlation between allelic frequencies, carriage rates and clinical manifestations of gout were evaluated.RESULTS:No significant differences were observed in the allelic frequencies and carriage rates of the IL-4 (promoter-590 and intron 3) and TNF-α gene polymorphisms between patients with gout and healthy control subjects. Furthermore, the IL-4 (promoter-590 and intron 3) and TNF-α genotypes were not found to be associated with the clinical and laboratory profiles in gout patients. However, there was a significant difference in the TNF-αpolymorphism genotype between patients with and without hypertriglyceridemia (P=0.001, &xgr;2 =11.47, OR=10.3, 95%CI= 3.57–29.7).CONCLUSIONS:The results of our study suggest that polymorphisms of the IL-4 (promoter-590 and intron 3) and TNF-α promoter-308 genes are not related to gout in Chinese patients in Taiwan.

【 授权许可】

Unknown