Clinical and Experimental Rheumatology | |
Anti-Clq antibodies in patients with chronic hepatitis C infection | |
K.E. Sherman1  G.Q. Shen1  D.W. Lienesch1  A. Metzger1  | |
关键词: MeSH; HCV; anti-Clq antibody; autoimmunity.; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
【 摘 要 】
OBJECTIVES: Extrahepatic autoinunune features of HCV infection include autoantibody production and the development of mixed cryoglobulinemia. Anti-Clq antibody, detected with high frequency in systemic lupus erythematosus and hypocomplementemic urticarial vasculitis, may have a direct pathogenic role in complement mediated autoimmune diseases. In this study, we investigate the prevalence of anti-Clq antibody in a population of patients with chronic HCV infection. METHODS: Serum was obtained from a group of 50 patients with chronic HCV infection and control groups comprised of patients with SLE, rheumatoid arthritis (RA), scleroderma (PSS), Sjögren`s syndrome (SS), mixed connective tissue disease (MCTD), and healthy individuals.RESULTS:Anti-Clq antibody was detected in 38% of HCV patients compared with 2% of healthy controls (p <0.0001). Levels were also significantly elevated in patients with SLE (61%), RA (20%), PSS (15%), SS (15%) and MCTD (15%).CONCLUSIONS:In addition to numerous other autoantibodies, patients with chronic HCV infection exhibit increased production of anti-Clq IgG antibodies. This observation may have implications for the pathogenesis of the mixed cryoglobulinemic vasculitis syndrome.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020415930ZK.pdf | 450KB | download |