Distal extremity swelling with pitting edema in psoriatic arthritis: A case-control study

Clinical and Experimental Rheumatology

L. Niccoli¹  C. Salvarani¹  P. Pavlica¹  L. Barozzi¹  I. Olivieri¹  L. Macchioni¹  C. Falcone¹  F. Cantini¹  A. Bozza¹  A. Padula¹  L. Boiardi¹ 

关键词: Psoriatic arthritis;    distal swelling with pitting edema;    tenosynovitis;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

B lymphocytes provide essential mechanisms of protection against infectious diseases. The secretion of specific antibodies by long-lived plasma cells is thought to account for the improved resistance afforded by most successful vaccines against pathogens. Accordingly, a goal in vaccine development is to induce potent B cell responses in order to drive the efficient formation of long-lived antibody-secreting cells. However, the roles of activated B cells are complex in infectious diseases. It was recently observed that activated B cells could also negatively regulate host defence mechanisms, both during primary infection and, after vaccination, upon secondary challenge, via mechanisms involving their production of the anti-inflammatory cytokines interleukin (IL)-10 and IL-35. Remarkably, the B cells expressing IL-10 and IL-35 in vivo were distinct subsets of IgMhiCD19+CD138hi antibody-secreting cells. A better understanding of the diverse roles of these distinct antibody-secreting cell subsets in immunity and immunological memory, as well as of the signals controlling their generation, might help the rational development of better prophylactic and therapeutic vaccines.

【 授权许可】

Unknown