Serologic and biochemical identification of minor histocompatibility (H-4) antigens.

The Journal of Immunology

C S David¹  P M Long¹  W P Lafuse¹ 

DOI  :  

学科分类：生物科学（综合）

来源: American Association of Immunologists

【 摘 要 】

Mouse alloantiserum capable of detecting minor histocompatibility antigens has been produced. Cytotoxic antibody to products of the H-4 locus was produced by reciprocal immunization of minor H loci congenic strains B10 (H-4a) and B10.129(21M) (H-4b), with mitogen-stimulated lymphocytes and epidermal cells. Absorption studies suggested antibodies to more than 1 specificity. The antibodies cross-react with products of other minor H loci. Alloantiserum to the H-4 gene product precipitates a glycoprotein with a m.w. of approximately 45,000 from radiolabeled Con A-stimulated lymph node cells.

【 授权许可】

Unknown