The role and structure of mitochondrial carriers

FEBS Letters

Kunji, Edmund R.S¹ 

[1] MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK

关键词: Mitochondrial carrier;    Electron crystallography;    X-ray crystallography;    Structure;    Membrane protein;   

DOI  :  10.1016/S0014-5793(04)00242-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Members of the mitochondrial carrier family transport compounds over the inner mitochondrial membrane to link the biochemical pathways in the cytosol with those in the mitochondrial matrix. X-ray crystallography has recently provided us with the first atomic model of the bovine ADP/ATP carrier, which is a member of this family. The structure explains the typical three-fold sequence repeats and signature motif of mitochondrial carriers. However, the carrier was crystallised as a monomer in detergent, which is inconsistent with the consensus that mitochondrial carriers exist as homo-dimers. The projection structure of the yeast ADP/ATP carrier by electron crystallography shows that carriers could form homo-dimers in the membrane.

【 授权许可】

Unknown