The archaeal sensory rhodopsin II/transducer complex: a model for transmembrane signal transfer

FEBS Letters

Gordeliy, Valentin I²  Büldt, Georg²  Steinhoff, Heinz-Jürgen¹  Labahn, Jörg²  Klare, Johann P³  Engelhard, Martin³ 

[1] Fachbereich Physik, Universität Osnabrück, Barbarastrasse 7 49069 Osnabrück, Germany;Research Centre Jülich, Institute of Structural Biology (IBI-2), 52425 Jülich, Germany;Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany

关键词: Phoborhodopsin;    Phototaxis;    Chemotaxis;    Signal transduction;   

DOI  :  10.1016/S0014-5793(04)00193-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Archaebacterial photoreceptors mediate phototaxis by regulating cell motility through two-component signalling cascades. Homologs of this sensory pathway occur in all three kingdoms of life, most notably in enteric bacteria in which the chemotaxis has been extensively studied. Recent structural and functional studies on the sensory rhodopsin II/transducer complex mediating the photophobic response of Natronomonas pharaonis have yielded new insights into the mechanisms of signal transfer across the membrane. Electron paramagnetic resonance data and the atomic resolution structure of the receptor molecule in complex with the transmembrane segment of its cognate transducer provided a model for signal transfer from the receptor to the cytoplasmic side of the transducer. This mechanism might also be relevant for eubacterial chemoreceptor signalling.

【 授权许可】

Unknown