FEBS Letters | |
LRRC8 involved in B cell development belongs to a novel family of leucine‐rich repeat proteins | |
Kubota, Keiko1  Hara, Junichi1  Ozono, Keiichi1  Kim, Ji Yoo1  Matsuda-Hashii, Yoshiko1  Fujisaki, Hiroyuki1  Sawada, Akihisa1  Tokimasa, Sadao1  | |
[1] Department of Developmental Medicine (Pediatrics), Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan | |
关键词: B cell development; Leucine-rich repeat; Gene family; BLASTp; protein–protein basic local alignment search tool; BLAT; basic local alignment tool; HGWD; Human Genome Project Working Draft database; LPS; lipopolysaccharide; LRR; leucine-rich repeat; LRRC8; leucine-rich repeat-containing 8; Pfam; Protein families database of alignments and HMMs; PBMCs; peripheral blood mononuclear cells; PHA; phytohemagglutinin; PMA; phorbol 12-myristate 13-acetate; | |
DOI : 10.1016/S0014-5793(04)00332-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
In a previous study, we isolated a novel gene, LRRC8 (leucine-rich repeat-containing 8), in a girl with congenital agammaglobulinemia. We have now identified four unknown LRRC8-like genes, named TA-LRRP, AD158, LRRC5, and FLJ23420. Their predicted structures are very similar to each other, and highly conserved between humans and the mouse. All five genes encode proteins consisting of 16 extracellular leucine-rich repeats (LRRs), all of which have four transmembrane regions except for FLJ23420. These genes belong to a novel family, designated the LRRC8 family, within the superfamily of LRR proteins. TA-LRRP, AD158, and LRRC5 might be implicated in proliferation and activation of lymphocytes and monocytes.
【 授权许可】
Unknown
【 预 览 】
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