LRRC8 involved in B cell development belongs to a novel family of leucine‐rich repeat proteins

FEBS Letters

Kubota, Keiko¹  Hara, Junichi¹  Ozono, Keiichi¹  Kim, Ji Yoo¹  Matsuda-Hashii, Yoshiko¹  Fujisaki, Hiroyuki¹  Sawada, Akihisa¹  Tokimasa, Sadao¹ 

[1] Department of Developmental Medicine (Pediatrics), Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan

关键词: B cell development;    Leucine-rich repeat;    Gene family;    BLASTp;    protein–protein basic local alignment search tool;    BLAT;    basic local alignment tool;    HGWD;    Human Genome Project Working Draft database;    LPS;    lipopolysaccharide;    LRR;    leucine-rich repeat;    LRRC8;    leucine-rich repeat-containing 8;    Pfam;    Protein families database of alignments and HMMs;    PBMCs;    peripheral blood mononuclear cells;    PHA;    phytohemagglutinin;    PMA;    phorbol 12-myristate 13-acetate;   

DOI  :  10.1016/S0014-5793(04)00332-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In a previous study, we isolated a novel gene, LRRC8 (leucine-rich repeat-containing 8), in a girl with congenital agammaglobulinemia. We have now identified four unknown LRRC8-like genes, named TA-LRRP, AD158, LRRC5, and FLJ23420. Their predicted structures are very similar to each other, and highly conserved between humans and the mouse. All five genes encode proteins consisting of 16 extracellular leucine-rich repeats (LRRs), all of which have four transmembrane regions except for FLJ23420. These genes belong to a novel family, designated the LRRC8 family, within the superfamily of LRR proteins. TA-LRRP, AD158, and LRRC5 might be implicated in proliferation and activation of lymphocytes and monocytes.

【 授权许可】

Unknown