Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus1

FEBS Letters

Cleveland, Thomas E¹  Bhatnagar, Deepak¹  Yu, Jiujiang¹ 

[1] U.S. Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, 1100 Robert E. Lee Boulevard, New Orleans, LA 70124, USA

关键词: Gene cluster;    Pathway evolution;    Aflatoxin;    Mycotoxin;    Secondary metabolite;    Aspergillus flavus;    NOR;    norsolorinic acid;    AVN;    averantin;    HAVN;    5′-hydroxy-averantin;    OAVN;    oxoaverantin;    AVF;    averufin;    VHA;    versiconal hemiacetal acetate;    VAL;    versiconal;    VERB;    versicolorin B;    VERA;    versicolorin A;    DMST;    demethylsterigmatocystin;    ST;    sterigmatocystin;    DHDMST;    dihydrodemethylsterigmatocystin;    DHST;    dihydrosterigmatocystin;    OMST;    O-methylsterigmatocystin;    DHOMST;    dihydro-O-methylsterigmatocystin;    AFB1;    aflatoxin B1;    AFB2;    aflatoxin B2;    AFG1;    aflatoxin G1;    AFG2;    aflatoxin G2;   

DOI  :  10.1016/S0014-5793(04)00327-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An 82-kb Aspergillus parasiticus genomic DNA region representing the completed sequence of the well-organized aflatoxin pathway gene cluster has been sequenced and annotated. In addition to the 19 reported and characterized aflatoxin pathway genes and the four sugar utilization genes in this cluster, we report here the identification of six newly identified genes which are putatively involved in aflatoxin formation. The function of these genes, the cluster organization and its significance in gene expression are discussed.

【 授权许可】

Unknown