FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial‐temporal patterns of expression of their transcripts

FEBS Letters

Lax, Irit¹  Laks, Shaked¹  Schlessinger, Joseph¹  Nakashima, Misako¹  Gotoh, Noriko¹ 

[1] Department of Pharmacology, Yale University School of Medicine, Sterling Hall of Medicine, 333 Cedar Street, B-204, New Haven, CT 06520, USA

关键词: Docking protein;    FRS2;    Fibroblast growth factor;    Neurotrophin;    Mitogen-activated protein kinase;    In situ hybridization;    FGF;    fibroblast growth factor;    NGF;    nerve growth factor;    DRG;    dorsal root ganglia;    VZ;    ventricular zone;    MEF;    mouse embryonic fibroblast;   

DOI  :  10.1016/S0014-5793(04)00287-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

FRS2α and FRS2β, two members of the FRS2 family of docking proteins, become tyrosine phosphorylated in response to fibroblast growth factor (FGF) or nerve growth factor (NGF) stimulation. Tyrosine phosphorylated FRS2α serves as a platform for the recruitment of multiple signaling proteins for activation of the Ras-mitogen-activated protein (MAP) kinase signaling cascade. We report that Frs2α and Frs2β have distinct spatio-temporal expression patterns in mouse embryos. We further show that FRS2β can compensate for the loss of FRS2α for activation of MAP kinase when expressed in fibroblasts from Frs2α ^−/− mouse embryos. We propose that the FRS2 family proteins have distinct roles in vivo through activation of common signaling proteins including MAP kinase.

【 授权许可】

Unknown