Mono‐unsaturated fatty acids protect against β‐cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure

FEBS Letters

Welters, Hannah J¹  Smith, Stephen A³  Morgan, Noel G¹  Tadayyon, Moh³  Scarpello, John H.B² 

[1] Institute of Biomedical and Clinical Science, Peninsula Medical School, Room N32, ITTC Building, Tamar Science Park, Plymouth, PL6 8BX, UK;School of Medicine, University of Keele, Keele, UK;GlaxoSmithKline Pharmaceuticals, Harlow, UK

关键词: β-Cell;    Lipotoxicity;    Apoptosis;    Diabetes;    Interleukin-1β;    Palmitoleate;    FFA;    free fatty acid;    iNOS;    inducible nitric oxide synthase;    IFNγ;    interferon-γ;    IL-1β;    interleukin-1β;   

DOI  :  10.1016/S0014-5793(04)00079-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Long-chain saturated fatty acids are cytotoxic to pancreatic β-cells while shorter-chain saturated and long-chain unsaturated molecules are better tolerated. Mono-unsaturated fatty acids are not, however, inert since they inhibit the pro-apoptotic effects of saturated molecules. In the present work we show that the mono-unsaturates palmitoleate (C16:1) or oleate (C18:1) also cause marked inhibition of apoptosis induced by exposure of clonal BRIN-BD11 β-cells to serum withdrawal or a combination of interleukin-1β plus interferon-γ. This response was dose-dependent and not accompanied by changes in NO formation. Taken together, the results suggest that mono-unsaturated fatty acids regulate a distal step common to several apoptotic pathways in pancreatic β-cells.

【 授权许可】

Unknown