Emerging neuroskeletal signalling pathways: a review

FEBS Letters

Hitchcock, Ian S¹  Genever, Paul G¹  Spencer, Gary J¹ 

[1] Biomedical Tissue Research, Department of Biology, University of York, York YO10 5YW, UK

关键词: Bone;    Marrow;    Nerve;    Neurotransmitter;    Osteoblast;    Osteoclast;   

DOI  :  10.1016/S0014-5793(04)00053-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recent work has demonstrated that neurotransmitters, signalling molecules primarily associated with the nervous system, can have profound effects on the skeleton. Bone cells express a broad range of neurotransmitter receptors and transporters, and respond to receptor activation by initiating diverse intracellular signalling pathways, which modulate cellular function. Evidence of neuronal innervation in skeletal tissues, neurotransmitter release directly from bone cells and functional effects of pharmacological manipulation support the existence of a complex and functionally significant neurotransmitter-mediated signalling network in bone. This review aims to concisely summarise our current understanding of how neurotransmitters affect the skeletal system, focusing on their origin, cellular targets and functional effects in bone.

【 授权许可】

Unknown